[Strain-, sex- and species-related differences of acetohexamide reductase and 20 beta-hydroxysteroid dehydrogenase activities in liver microsomes of experimental animals] Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. [Yakugaku Zasshi] Journal article | | Title | [Strain-, sex- and species-related differences of acetohexamide reductase and 20 beta-hydroxysteroid dehydrogenase activities in liver microsomes of experimental animals] | | Author(s) | Imamura Y, Uchida A, Takada H, Otagiri M, Tsuchiya K | | Institution | Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1, Oe-honmachi, Kumamoto 862-0973, Japan. | | Source | Yakugaku Zasshi 2001 Jan; 121(1):85-91. | | MeSH | 20-Hydroxysteroid Dehydrogenases
Alcohol Oxidoreductases
Animals
English Abstract
Female
Male
Mice
Microsomes, Liver
Rabbits
Rats
Rats, Inbred Strains
Sex Characteristics
Species Specificity
| | Abstract | We examined physiological and genetic factors affecting acetohexamide reductase (AHR) and 20 beta-hydroxysteroid dehydrogenase (20 beta-HSD) activities in liver microsomes of experimental animals. Pronounced strain-related differences were found in both activities of AHR and 20 beta-HSD present in liver microsomes of male rats. Among rat strains tested in this study, even though a Wistar-Imamichi (WIM) rat strain was taken to lack AHR activity, it exhibited a significant 20 beta-HSD activity. These findings appeared to be in conflict with our conclusion reported so far, which AHR and 20 beta-HSD present in liver microsomes of male rats are identical enzymes. Thus the reason for this discrepancy was discussed. Furthermore, AHR and 20 beta-HSD activities were little or not observed in liver microsomes of female rats or male experimental animals other than the rat, indicating the existence of sex- and species-related differences in these two enzyme activities. | | Language | jpn | | Pub Type(s) | Journal Article
| | PubMed ID | 11201165 |
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